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Proposed Acceptability for PACR2004-39
Continuing Registration
Re-evaluation of 5-Chloro-2-methyl-3(2H)-isothiazolone
and 2-Methyl-3(2H)-isothiazolone
The purpose of this document is to inform registrants, pesticide regulatory officials and the Canadian
public that the Pest Management Regulatory Agency (PMRA) has completed a re-evaluation of
5-chloro-2-methyl-3(2H)-isothiazolone (IST) and 2-methyl-3(2H)-isothiazolone (ISL). The PMRA
has determined that IST and ISL are acceptable for continued registration provided that the proposed
mitigation measures are adopted. Additional data requirements are identified. Upon finalization of
the re-evaluation decision, the PMRA will provide registrants of products containing IST and ISL
with specific direction on how to address these measures and requirements.
This Proposed Acceptability for Continuing Registration (PACR) document provides a rationale for
the proposed regulatory decision for IST and ISL. The PMRA will accept written comments on this
proposal up to 45 days from the date of publication of this document. Please forward all comments to
the Publications Coordinator at the address below.
(publié aussi en français) 19 October 2004
This document is published by the Alternative Strategies and Regulatory Affairs Division,
Pest Management Regulatory Agency. For further information, please contact:
Publications Coordinator Internet: [email protected]
Pest Management Regulatory Agency www.pmra-arla.gc.ca
Health Canada Information Service:
2720 Riverside Drive 1 800 267-6315 or (613) 736-3799
A.L. 6605C Facsimile: (613) 736-3758
Ottawa, Ontario
K1A 0K9
ISBN: 0-662-38421-0 (0-662-38422-9)
Catalogue number: H113-18/2004-39E (H113-18/2004-39E-PDF)
© Her Majesty the Queen in Right of Canada, represented by the Minister of Public Works and Government Services
Canada 2004
All rights reserved. No part of this information (publication or product) may be reproduced or transmitted in any form or by any
means, electronic, mechanical photocopying, recording or otherwise, or stored in a retrieval system, without prior written
permission of the Minister of Public Works and Government Services Canada, Ottawa, Ontario K1A 0S5.
Table of Contents
1.0 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
2.0 Re-evaluation of IST and ISL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
3.0 Proposed re-evaluation decision . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
4.0 Proposed regulatory actions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
5.0 Additional data requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
6.0 Supporting documentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Appendix I Products containing IST/ISL registered in Canada as of 31 March 2004 . . . . . . 9
Proposed Acceptability for Continuing Registration - PACR2004-39
1.0 Background
The PMRA is re-evaluating all pesticides, both active ingredients and formulated end-use
products (EPs), that were registered prior to 31 December 1994 to ensure that their
continued acceptability is examined using current scientific approaches. Regulatory
Directive DIR2001-03, PMRA Re-evaluation Program, presents the details of the
re-evaluation activities and program structure.
IST and ISL have been re-evaluated by the PMRA under Re-evaluation Program 1 as
described in DIR2001-03. Under Program 1, the PMRA relies as much as possible on
foreign reviews, typically United States Environmental Protection Agency (USEPA)
Reregistration Eligibility Decision (RED) documents, to assess Canadian pest control
products. For products to be re-evaluated under Program 1, there must exist a suitable
foreign review that meets the following conditions:
• it covers the main science areas, such as human health and the environment, that
are necessary for Canadian regulatory decisions;
• it addresses the active ingredient and the main formulation types registered in
Canada; and
• it is relevant to registered Canadian uses.
Based on the outcome of foreign reviews, the PMRA will propose, under Program 1,
a regulatory decision and appropriate mitigation measures for Canadian uses of an
active ingredient.
The USEPA conducted a re-evaluation of IST and ISL and concluded that, on the basis of
health and environmental risk assessments, they were eligible for reregistration with the
implementation of mitigation measures. These conclusions were published in a 1998
RED document. In its re-evaluation of IST and ISL, the PMRA based its conclusions on
this 1998 RED document, taking into account the Canadian use pattern and Canadian
issues (e.g., the federal Toxic Substances Management Policy [TSMP]). A review of the
chemistry of the Canadian technical active ingredients was also conducted.
Proposed Acceptability for Continuing Registration - PACR2004-39
2.0 Re-evaluation of IST and ISL
Active 5-Chloro-2-methyl-4-isothiazolin-3- 2-Methyl-4-isothiazolin-3-one
substance: one (IST) (ISL)
IUPAC 5-Chloro-2-methyl- 2-Methyl-3(2H)isothiazolone
name: 3(2H)isothiazolone
CAS name: 5-Chloro-2-methyl-4-isothiazolin-3- 2-Methyl-4-isothiazolin-3-one
one
CAS 26172-55-4 2682-20-4
number:
In Canada, IST and ISL were first registered in 1978. IST and ISL always occur together
in the currently registered Canadian technical and end-use products in approximately a
3:1 ratio, and this mixture will henceforth be referred to as IST/ISL. According to current
EP labels, it is registered in Canada for controlling slime-forming bacteria, fungi and
algae in:
• oil field injection waters
• drilling muds and workover or completion fluids
• well stimulation and fracturing (guar gum based)
• recirculating cooling water systems
• evaporative condensers
• heat exchange water systems
• commercial and industrial cooling towers
• influent systems, such as flow through filters, settling ponds and lagoons
• industrial water scrubbing systems
• brewery pasteurizers and can warmers
• hydrostatic cookers and retort waters
• auxiliary water/service water and waste water systems
• fire protection systems
• pump or screen bays
• waste material disposal
• holding or recovery systems such as storage tanks
• storage piles
• associated piping
• transport spillways or canals
• disposal wells
• specialty industrial products
• hydraulic fluids
• conveyor lubricants
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 2
• industrial and household consumer products (all-purpose cleaners,
polishes, anti-tarnish products, solid air freshener, carpet shampoos,
pre-spotters)
• liquid dishwashing detergents
• automotive appearance products
• liquid laundry products
• printing inks and printing ink components
• photo processing systems (motion picture, radiographic, micrographic,
graphic arts, photoprocessing film)
• lithographic printing components
• photo plate processing chemicals
• package utility products (i.e. pre-moistened sponges and mops)
• cutting oils
• fuel preservation (aviation fuels, kerosene, heating oils, diesel fuels, residual oils,
coal slurries, liquified petroleum gases, petrochemical feedstocks)
• cooling towers
• pulp and paper mills
• industrial process water (including recirculating electrodeposition systems)
• air washers
• adhesives and paints (aqueous paints, inks, mastics, joint cements, caulks, slurries,
concrete additives)
• industrial coatings
• polymer latices (acrylic, styrene/butadiene, carboxylated styrene/butadiene,
ethylene, vinyl acetate, polyvinyl acetate, starch-based emulsions)
• biopolymers intended for industrial use, such as xanthan gum, gum arabic, guar
gum, protein-derived polymers, starches and casein-derived polymers
• dispersed pigment preservation (kaolin clay, montmorillite clay titanium dioxide
calcium carbonate, calcium sulfate, barium sulfate, magnesium silicate, kieselguhr
used in paint and paper productions)
• wood and wood products such as landscape timbers, fences, posts, pilling, cross
ties, decks and similar structures (tank-mixed with chromated copper arsenate
[CCA])
Currently registered Canadian products containing IST/ISL are listed in Appendix I.
Based on the comparison of American and Canadian use patterns, the USEPA assessment
described in the RED document for IST/ISL is considered to be an adequate basis for the
proposed Canadian re-evaluation decision. The details of the assessments conducted by
the USEPA are presented in the USEPA RED for IST/ISL.
The federal TSMP and Regulatory Directive DIR99-03 were taken into consideration
during the review of IST/ISL, and it was concluded that neither IST nor ISL are TSMP
Track 1 substances. The technical products are not expected to contain impurities of
toxicological concern as identified in Regulatory Directive DIR98-04 or TSMP Track 1
substances as identified in Appendix II of DIR99-03.
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 3
3.0 Proposed re-evaluation decision
The USEPA published a RED document for IST/ISL addressing the main science areas
that are necessary for Canadian regulatory decisions, i.e., human health and the
environment. This document addressed uses of IST/ISL that are also registered in Canada.
Based on the USEPA RED and Canadian use pattern, the PMRA has determined that
IST/ISL is acceptable for continued registration provided that the mitigation measures
specified in Section 4.0 are adopted. Additional data requirements are identified in
Section 5.0.
It should be noted that for EPs containing more than one active ingredients under
re-evaluation, registration status might change as a result of the re-evaluation of the
remaining affected active ingredients.
The PMRA will accept written comments on this proposal up to 45 days from the date of
publication of this document to allow interested parties an opportunity to provide input
into the proposed re-evaluation decision. Registrants of products containing IST/ISL
should not apply for label amendments or submit the additional data described in
Section 5.0 during this comment period; they will be informed by letter of the specific
instructions for addressing label changes and data requirements once the re-evaluation
decision has been finalized.
4.0 Proposed regulatory actions
Based on the USEPA RED and in consideration of the Canadian use pattern, all Canadian
EP labels must be amended as follows to further protect workers and the environment.
• On the primary display panel, the following statement must be added:
• “POTENTIAL SKIN SENSITIZER.”
• In the “Precautions” section, the following statements are required:
1) For all EPs,
• “Potential skin sensitizer.”
• “Do not get in eyes, on skin, or on clothing. Do not swallow. Avoid
breathing vapours and spray mists. Wash skin thoroughly with soap and
water after handling. Remove contaminated clothing and wash separately
from other laundry before reuse.”
2) For products with registration numbers 19229 and 25661,
• “Avoid contamination of food.”
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 4
3) For all EPs, except for products formulated as premeasured packets,
• “Wear long pants, a long-sleeved shirt, chemical-resistant gloves, a full
face NIOSH-approved respirator and a chemical-resistant apron during
mixing/loading, clean up and repair.”
4) For products applied as a spray (e.g., on waste piles),
• “For spray application, wear chemical-resistant gloves, a full face
NIOSH-approved respirator, chemical-resistant coveralls and rubber boots
during mixing/loading, application, clean up and repair.”
5) For the product with Registration Number 18203, which is formulated as
premeasured packet,
• “Wear long pants, a long-sleeved shirt and chemical-resistant gloves
during mixing/loading, clean up and repair.”
• In the “Environmental Hazards” sub-section of the “Precautions” section, the
following statements must be added:
1) For all EPs,
• “This product is toxic to fish and other aquatic organisms. It is not to be
used in circumstances that would cause or allow it to enter lakes, streams,
ponds, estuaries, oceans or other waters in contravention of federal or
provincial regulatory requirements. The requirements of applicable laws
should be determined before using the product.”
2) For products used on wood and wood products,
• “Store treated lumber on a roofed drip pad until dripping has ceased. Slope
lumber on the drip pad to expedite drainage and to ensure that no puddles
remain on the surface of the wood. Contain drippage and other related
wastes to prevent release in the environment.”
• “DO NOT expose treated lumber to heavy rains immediately after
treatment. DO NOT float treated lumber in lakes, rivers, streams, or
oceans.”
• In the “Directions for Use” section, for products used on wood and wood
products, the label must be modified so that it is not in contradiction with CCA
treated wood use limitations. In addition, the following statement must be added,
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 5
• “For further information on storage, handling, use, and disposal of treated
wood, contact the manufacturer of this product or the provincial regulatory
agency.”
The label amendments presented above do not include all label requirements for
individual EPs, such as first aid statements, disposal statements, precautionary statements
and supplementary protective equipment. Additional information on labels of currently
registered products should not be removed unless it contradicts the above label
statements.
A submission to request label revisions is required within 90 days of finalization of the
re-evaluation decision. Registrants should note that for products with dual classification
(i.e. classified both as technical or manufacturing and as commercial), an application to
register a separate commercial EP is required and the label of the technical or
manufacturing use product must be amended to remove references to commercial uses.
Some Canadian EPs containing IST/ISL are registered for use at maximum application
rates higher than those registered in the United States (products with registration numbers
18131, 19002, 21155, 21802, 26231 and 26662 for cooling towers; the product with
registration number 25529 for cutting oils; and the product with registration number
28102 for air washers). Registrants of these Canadian EPs are required to submit a
rationale to support these maximum application rates or to lower their rates on the label.
This is required within 90 days of finalization of the re-evaluation decision.
5.0 Additional data requirements
The technical registrant(s) of IST/ISL is required to submit the following within
24 months of finalization of the re-evaluation decision:
• all data (as they relate to the Canadian use pattern) submitted to the USEPA in
response to the data call-in prior to the reregistration in the United States and
USEPA Data Evaluation Reports (DERs);
• all data (as they relate to the Canadian use pattern) that were required by the
USEPA as a condition of reregistration of IST/ISL; and
• a commitment and schedule to address Canadian requirements that are not
addressed through submission of the data outlined above. These are outlined in
the PMRA’s data code (DACO) tables for use-site categories (USC) #17, #18, #19
and #23. The registrant is required to address the following sections of DACO
tables:
• for the TGAI: DACOs 2 through 9, inclusive
• for the EP: DACOs 5, 8, and 9
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 6
Normally, DACO 5.6 or 5.7 is conditionally required for Use-site Category #18; however,
as a result of the sensitization concern for IST/ISL, this data is required.
To assess the potential sensitization risk to workers and consumers handling treated
materials containing IST and ISL, the EP registrants are required to generate a localized
lymph node assay (DACO 4.6.6, OECD Test Guideline 429) and postapplication
exposure data (DACO 5.6 or 5.7) for all material preservative uses of IST and ISL
(including, but not limited to, metalworking fluids, adhesives, paints, polymer latices,
industrial product, household consumer products, liquid dishwashing detergents,
polymers latex emulsions, etc.).
The registrants should be advised that the localized lymph node assay data should be
conducted with the liquid treated materials (e.g., dishwashing detergents, latex emulsions,
adhesives, metalworking fluids). The postapplication exposure will assess the potential
for sensitization to workers and consumers using the data from the localized lymph node
assay. The data requirement must be addressed for each treated material identified on the
label, either through data specific to the treated material or a scientific rationale. The
registrants may wish to consider clustering several similar treated materials together or
conducting a sensitization risk assessment for the worst case scenario and providing a
scientific rationale justifying this approach.
The above data and additional data may be required sooner if expansion of current uses of
IST/ISL is requested.
The PMRA is currently undertaking initiatives to address the labelling deficiencies for
certain kinds of antimicrobial products, especially with respect to the “Directions for
Use” section of product labels. The PMRA will announce in the near future the nature of
these initiatives and any requirements to be addressed by registrants.
6.0 Supporting documentation
PMRA documents, such as DIR2001-03, and DACO tables can be found on our website
at www.pmra-arla.gc.ca. PMRA documents are also available through the Pest
Management Information Service. Phone: 1 800 267-6315 within Canada or
1 (613) 736-3799 outside Canada (long distance charges apply); Fax: (613) 736-3798;
E-mail: [email protected]
The federal TSMP is available through Environment Canada’s website at
www.ec.gc.ca/toxics.
The USEPA RED document (Methylisothiazolinone) is available on the Office of
Pesticide Programs’ website at www.epa.gov/pesticides/reregistration under Chemical
Status.
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 7
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 8
Appendix I
Appendix I Products containing IST/ISL registered in Canada as of
31 March 2004
Product name Registrant Registration Guarantee (%) Class*
number
Kathon 886 MW Microbiocide Rohm and Haas Canada Inc. 15245 IST: 10.5 C
ISL: 3.5
Chemcide #2 Metalworking Chem-Ecol Ltd. 15352 IST: 1.05 C
Fluid Microbicide ISL: 0.35
Kathon WT Papermill Rohm and Haas Canada Inc. 15548 IST: 10.5 C
Slimicide ISL: 3.5
Amerstat 320 Liquid for Drew Canada, Ashland 15592 IST: 1.72 C
Microbiological Control Canada Corp. ISL: 0.52
Spectrum RX6202 Pulp & Hercules Canada (2002) 17235 IST: 2.3 C
Paper Microbistat Inc. ISL: 0.7
Nalco 7330 Cooling Water Nalco Canada Co. 17338 IST: 1.13 C
Slimicide ISL: 0.37
Slime-Trol RX-68 Papermill Hercules Canada (2002) 17390 IST: 1.13 C
Antimicrobial Agent Inc. ISL: 0.37
Spectrus NX1106 GE Betz Canada 17391 IST: 1.13 C
ISL: 0.37
Grotan FS Metalworking Gray Products, Troy 17408 IST: 10.5 C
Microbiocide Chemical Company Limited ISL: 3.5
Raisio 286X Liquid Slimicide Raisio Chemicals Canada 17427 IST: 2.25 C
Inc. ISL: 0.75
Nalcon 7647 Slimicide Nalco Canada Co. 17444 IST: 1.15 C
Microbiological Control ISL: 0.35
Chemical
Kathon LX Polymer Latex Rohm and Haas Canada Inc. 17445 IST: 10.5 C
Preservative ISL: 3.5
Kathon WT 1.5% Solution Rohm and Haas Canada Inc. 17446 IST: 1.13 C
Papermill Slimicide ISL: 0.37
Kathon LX 1.5% Polymer Rohm and Haas Canada Inc. 17447 IST: 1.13 C
Latex Preservative ISL: 0.37
Quatic Chemicals Series 3006 Quatic Industries Inc. 17695 IST: 1.13 C
Liquid Industrial Biocide ISL: 0.37
Kathon CG/ICP Industrial Rohm and Haas Canada Inc. 17726 IST: 1.13 C
Microbicide ISL: 0.37
Magnatrol 41-A Produits Chimiques Magnus 17962 IST: 2.63 C
Ltée ISL: 0.88
ML-27 Liquid Microbicide Rochester Midland Limited 17981 IST: 1.15 C
ISL: 0.38
Kathon MWX Microbicide Rohm and Haas Canada Inc. 18203 IST: 4.7 C
ISL: 1.6
Grotan U-15 Metalworking Gray Products, Troy 18245 IST: 1.134 C
Micro-biocide Chemical Company Limited ISL: 0.378
Formula MMD-3480 Industrial Nalco Canada Co. 18313 IST: 1.13 C
Liquid Slimicide ISL: 0.37
Chemicide #5 Metalworking Chem-Ecol Ltd. 18317 IST: 8.6 C
Fluid Microbicide ISL: 2.6
Quaker Biocide 300 Blachford, H.L. Ltd. 18411 IST: 8.6 C
ISL: 2.6
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 9
Appendix I
Product name Registrant Registration Guarantee (%) Class*
number
Busan 1078 Liquid Buckman Laboratories of 19001 IST: 1.12 C
Microbicide Canada, Ltd. ISL: 0.38
Busan 1081 Liquid Buckman Laboratories of 19002 IST: 2.84 C
Microbicide Canada, Ltd. ISL: 0.95
Amerstat 325 Microbiocide for Drew Canada, Ashland 19029 IST: 2.24 C
Metalworking Fluids Canada Corp. ISL: 0.75
Biosperse 250 Cooling Tower Drew Canada, Ashland 19076 IST: 1.125 C
Microbiocide Canada Corp. ISL: 0.375
Nalco 6C40 Slimicide Nalco Canada Co. 19229 IST: 2.898 C
Microbiological Control ISL: 0.966
Chemical
X-Cide 207 Baker Petrolite Corporation 19368 IST: 5.25 C
ISL: 1.75
Biomate SAN9366 GE Betz Canada 19393 IST: 2.1 C
ISL: 0.7
Kathon CG/ICP II Microbicide Rohm and Haas Canada Inc. 19697 IST: 1.13 C
In-container Preservative ISL: 0.37
Kathon 886 MW 1.5% Rohm and Haas Canada Inc. 19830 IST: 1.13 C
Metalworking Fluid ISL: 0.37
Microbicide
Isothiocide Microbiocide Drew Canada, Ashland 20506 IST: 1.125 C
Canada Corp. ISL: 0.375
Aquarian C-407 Water Cooling Aquarian Chemicals Inc. 21155 IST: 0.29 C
Tower Microbicide ISL: 0.09
Thor Acticide SPX-C Polymer Thor GmbH 21427 IST: 1.12 C
Latex Preservative ISL: 0.38
Kathon 886 Technical Rohm and Haas Canada Inc. 21799 IST: 10.5 T
Industrial Microbiocide ISL: 3.5
ControlChem 2650 Industrial ControlChem Canada Ltd. 21802 IST: 1.13 C
Liquid Microbiocide ISL: 0.37
Kathon PFM Printing Fluid Rohm and Haas Canada Inc. 21966 IST: 1.13 C
Microbicide ISL: 0.37
Kathon FP 1.5 Industrial Rohm and Haas Canada Inc. 21970 IST: 1.13 C
Microbicide ISL: 0.37
Kathon FP Industrial Rohm and Haas Canada Inc. 22039 IST: 10.5 C
Microbicide ISL: 3.5
Biosperse 1740 Industrial Drew Canada, Ashland 22147 IST: 10.5 C
Microbicide Canada Corp. ISL: 3.5
IsoKlenz KT Klenzoid Co., Ltd. 22260 IST: 0.37 C
ISL: 1.13
Kathon ED Industrial Biocide Rohm and Haas Canada Inc. 22382 IST: 10.5 C
ISL: 3.5
Kathon EDC 1.5% Industrial Rohm and Haas Canada Inc. 22386 IST: 1.13 C
Microbiocide ISL: 0.37
H-510 Microbiocide Nalco Canada Co. 22485 IST: 1.13 C
ISL: 0.37
Metasol CMI-150 Paper Mill Nalco Canada Co. 22486 IST: 1.13 C
Slimicide ISL: 0.37
Aquarian C406 Aquarian Chemicals Inc. 22560 IST: 1.13 C
ISL: 0.37
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 10
Appendix I
Product name Registrant Registration Guarantee (%) Class*
number
IsoKlenz RW Klenzoid Co., Ltd. 22564 IST: 0.565 C
ISL: 0.185
Magnacide MW (Control of Produits Chimiques Magnus 22765 IST: 2.63 C
Bacteria) Ltée ISL: 0.88
AMA-415C A Mineral Slurry Kemira Chemicals, Inc. 22799 IST: 0.37 C
Preservative ISL: 1.13
X-cell 426 Papermill Slimicide DiverseyLever Canada Inc. 22895 IST: 0.37 C
ISL: 1.13
Nalco 7647 Cooling Water Nalco Canada Co. 22946 IST: 1.13 C
Slimicide ISL: 0.37
Spectrus NX1111 Microbicide GE Betz Canada 22952 IST: 1.31 C
ISL: 0.44
Glutaraldehyde: 7.5
Amerstat 251 Biocide Drew Canada, Ashland 23162 IST: 1.125 C
Canada Corp. ISL: 0.375
VIP 915 Slimicide Venerus International 23291 IST: 1.13 C
Microbiocide Purification Inc. ISL: 0.37
VIP 915 MW Microbiocide Venerus International 23294 IST: 0.37 C
Purification Inc. ISL: 1.13
Legend MK Microbicide Rohm and Haas Canada Inc. 23394 IST: 1.13 C
In-container Preservative ISL: 0.37
Omnitrol Formula 300-K Nalco Canada Co. 23564 IST: 0.28 C
Liquid Microbicide ISL: 0.09
Omnitrol Formula 600-K Nalco Canada Co. 23595 IST: 0.142 C
Liquid Microbicide ISL: 0.047
AMA-115-C Papermill Vinings Industries Inc. 23747 IST: 1.13 C
Slimicide ISL: 0.37
Spec-aid 8Q700 (Industrial GE Betz Canada 23911 IST: 1.13 C
Microbicide) ISL: 0.37
Omnitrol 600-CK Liquid Nalco Canada Co. 23927 IST: 0.142 C
Microbicide (Non Foaming) ISL: 0.047
Omnitrol 300-CK Liquid Nalco Canada Co. 23930 IST: 0.28 C
Microbicide (Non Foaming) ISL: 0.09
Bulab 6057 Liquid Microbicide Buckman Laboratories of 24001 IST: 1.13 C
Canada, Ltd. ISL: 0.37
Gax-26 Industrial Recirulation DiverseyLever Canada Inc. 24220 IST: 1.13 C
Water Cooling Tower ISL: 0.37
Microbicide
ControlChem 2729 A ControlChem Canada Ltd. 24373 IST: 1.13 C
Metalworking Microbicide ISL: 0.37
Kathon 886f Industrial Rohm and Haas Canada Inc. 24535 IST: 10.5 C
Microbicide ISL: 3.5
Arch Mold Inhibitor K-18500 Arch Wood Protection 24624 IST: 10.5 C
Canada Corp. ISL: 3.5
Timber Specialties Mold Timber Specialties Co. 24791 IST: 10.5 C
Inhibitor ISL: 3.5
Kathon SF-886 Technical Rohm and Haas Canada Inc. 24982 IST: 74.3 C+T
Microbicide ISL: 24.2
Proposed Acceptability for Continuing Registration - PACR2004-39
Page 11
Appendix I
Product name Registrant Registration Guarantee (%) Class*
number
Eclipse 602 Microbicide Buckman Laboratories of 25220 IST: 1.13 C
Canada, Ltd. ISL: 0.37
Supatimber H.E. 14 Wood Chemical Specialties Inc. 25389 IST: 10.5 C
Mildewcide ISL: 3.5
Spectrum RX6820 Slime Hercules Canada (2002) 25501 IST: 0.97 C
Control Agent Inc. ISL: 2.90
Process B1003 Paper Mill E.Q.U.I.P. International Inc. 25515 IST: 2.26 C
Slimicide ISL: 0.74
Biomate SAN9363 GE Betz Canada 25529 IST: 1.13 C
Antimicrobial Agent ISL: 0.37
Spectrum RX9100 Hercules Canada (2002) 25660 IST: 1.9 C
Antimicrobial Agent Inc. ISL: 0.6
Bronopol: 5.3
Spectrus NX1100 GE Betz Canada 25661 IST: 1.9 C
ISL: 0.6
Bronopol: 5.3
WCS 102 Industrial Ecolab Textile Care 25694 IST: 0.37 C
Recirculating Water Cooling Division ISL: 1.13
Tower Microbiocide
Biomate SAN9361 GE Betz Canada 25722 IST: 1.9 C
Antimicrobial Agent ISL: 0.6
Bronopol: 5.5
Biochek 430 Bayer Chemical 25731 IST: 0.059 C
Corporation ISL: 0.018
1,2-dibromo-2,4-
dicyanobutane:
23.725
Kathon CF 150 Microbicide Rohm and Haas Canada Inc. 25888 IST: 1.13 C
ISL: 0.37
Mitco CC-33L Papermill Mitco Inc.


Use: 0.0699